Petroleum extracts of Cynanchum cutum L. and structure elucidation of isolated compounds

  • Rajni Singh Khureja
  • Dinesh Kumar
Keywords: Structure Elucidation, Cynanchum cutum L., Natural Product, Petroleum Extracts


In present study, petroleum ether extracts of Cynanchum cutum L. isolated unknown active constituents and their structure elucidated by analytical technique. The extracts were analyzed by the GC/MS technique. The GC chromatogram showed nine peaks corresponding to four compounds. These four compounds were identified on the basis of a high percentage of matching with authentic spectrum using NIST library.


1. Ahmed S. A.; Ross S. A.; Slade D., Radwan M. M. Zulfiqar F, Matsumoto R. R; Xu Y. T, Viard E, Speth R. C, Karamyan V. T., ElSohly M. A. Cannabinoid ester constituents from high-potency Cannabis sativa. J. Nat. Prod. 2008; 71: 536-42.
2. Ghosh A., Ghosh T. Herbal drugs of abuse. Syst. Rev. Pharm. 2010; 1: 141-145.
3. McClatchey W. C., Mahady G. B., Bennett B. C., Shiels L., Savo V. Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources. Pharmacol. Ther. 2009; 123: 239-54.
4. Patel J, Amrutiya J, Bhatt P, Javia A, Jain M, Misra A. Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells. Journal of Microencapsulation. 2018;35(2):204-17.
5. Vhora I, Patil S, Bhatt P, Misra A. Protein- and Peptide-drug conjugates: an emerging drug delivery technology. Advances in protein chemistry and structural biology. 2015;98:1-55.
6. Mangal M., Sagar P., Singh H, Raghava G. P. S., Agarwal S. M. NPACT: Naturally occurring plant-based anti-cancer compound-activity-target database. Nucleic Acids Res. 2013; 41: D1124-D1129.
7. Abdullaev F. I., Espinosa-Aguirre J. J. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect. Prev. 2004; 28: 426-32.
8. Baker J. T., Borris R. P., Carte B., Cordell G. A, Soejarto D. D, Cragg G. M, Gupta M. P, Iwu M. M, Madulid D. R, Tyler V. E. Natural product drug discovery and development - New perspectives on international collaboration. J. Nat. Prod. 1995; 58: 1325-57.
9. Amin A, Gali-Muhtasib H, Ocker M., Schneider-Stock R. Overview of major classes of plant-derived anticancer drugs. Int. J. Biomed. Sci. (Pomona, CA, U. S.) 2009; 5:1-11.
10. Lee K. H. Current developments in the discovery and design of new drug candidates from plant natural product leads. J. Nat. Prod. 2004; 67: 273-83.
11. Cragg G. M., Newman D. J. Plants as a source of anti-cancer agents. J. Ethnopharmacol. 2005; 100: 72-9.
12. Lee K. H. Anticancer drug design based on plant-derived natural products. J. Biomed. Sci. (London, U. K.) 1999; 6:236-50.
13. Mahidol C, Ruchirawat S, Prawat H., Pisutjaroenpong S, Engprasert S, Chumsri P, Tengchaisri T., Sirisinha S., Picha P. Biodiversity and natural product drug discovery. Pure Appl. Chem. 1998; 70:2065-72.
14. Cragg G. M. Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development. Med. Res. Rev. 1998; 18:315-31.
15. Bhatt P, Vhora I, Patil S, Amrutiya J, Bhattacharya C, Misra A, et al. Role of antibodies in diagnosis and treatment of ovarian cancer: Basic approach and clinical status. Journal of controlled release : official journal of the Controlled Release Society. 2016;226:148-67
How to Cite
Khureja, R. S., and D. Kumar. “Petroleum Extracts of Cynanchum Cutum L. And Structure Elucidation of Isolated Compounds”. Himalayan Journal of Health Sciences, Vol. 4, no. 1, Jan. 2019, pp. 1-6, doi:10.22270/ijist.v4i1.34.
Original Articles