Carica papaya leaves: One of dynamic plant parts having multiple therapeutic activities

  • Parin S Sidat Department of Pharmaceutical Chemistry, Shree Dhanvatary Pharmacy College, Kim, Surat
  • Aysha I. Varachia
  • Shivangini K. Vanshiya
  • Ajay H. Unagar
  • Meet G. Akbari
  • Rupin C. Dhamat


Introduction: Papaya (Carica papaya Linn.) belongs to the Caricaceae family. Papaya is well known around the world for its medicinal and nutritional properties. Various parts of the plant like, fruits, roots, bark, peel, seeds and pulp are known to have medicinal properties and scientifically established for the various properties. Since the ancient times, part of plants has been utilized for their medicinal values. The plant contains high amount of vitamins A, B and C as well as proteolytic enzyme such as papain and chymopapain. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological application. In this review article we summarized the information regarding the various pharmacological activities of papaya leaf such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antisickling, antioxidant, antimicrobial, antimalarial, as well as helps in proper digestion, hair growth, skin related problems and relief in menstrual pain.

Methods: All information presented in this review article regarding the beneficial application of Carica papaya leaf extract has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of science, and PubMed.

Result: The papaya plant, including fruit, leaves, seed, bark, latex and its ingredients, plays an important part in the management of progressive illness. The papaya leaf contains active ingredients such as alkaloids, glycosides, phenols, tannins, saponins and the flavonoids responsible for the basketful therapeutic function.

Conclusion: The main findings showed that papaya leaf extract has strong medicinal properties. The leaves of papaya may also useful in cosmetic applications.

Keywords: Carica papaya leaves, phytochemical constituents, therapeutic application


1. Article R. Basketful Benefits of Papaya. Int Res J Pharm. 2011; 2(7):6–12.
2. Anjum V, Ansari SH, Naquvi KJ, Arora P, Ahmad A. Development of quality standards of Carica Papaya Linn . leaves. Scolar Res Libr. 2013; 5(July 2012):370–6.
3. Aravind G, Bhowmik D, Duraivel S, Harish G. Traditional and Medicinal Uses of Carica papaya. J Med Plants Stud. 2013; 1(1):7–15.
4. Krishna KL, Paridhavi M, Patel JA. Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya linn.). Indian J Nat Prod Resour. 2008; 7(4):364–73.
5. Fauziya S, Krishnamurthy R. Papaya (Carica Papaya): Source Material for Anticancer. CIBTech J Pharm Sci. 2013; 2(1):2319–389125.
6. Leader B, Baca QJ, Golan DE. Protein therapeutics: A summary and pharmacological classification. Nat Rev Drug Discov. 2008;7(1):21–39.
7. Akhila S, Vijayalakshmi NG. Phytochemical Studies on Carica Papaya Leaf Juice. Int J Pharm Sci Res. 2015; 6(2):880–3.
8. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2010; 127(3):760-7.
9. Singh SP, Mishra A, Shyanti RK, Singh RP, Acharya A. Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells. Biol Trace Elem Res; 2020
10. Jain A, Ahmad F, Gola D, Malik A, Chauhan N, Dey P, et al. Multi dye degradation and antibacterial potential of Papaya leaf derived silver nanoparticles. Environ Nanotechnology, Monit Manag [Internet]. 2020 [cited 2020 May 13]; 14:100337. Available from:
11. Bhuiyan MSH, Miah MY, Paul SC, Aka T Das, Saha O, Rahaman MM, et al. Green synthesis of iron oxide nanoparticle using Carica papaya leaf extract: application for photocatalytic degradation of remazol yellow RR dye and antibacterial activity. Heliyon [Internet]. 2020 [cited 2020 May 14]; 6(8):e04603. Available from:
12. Saleem M, Cheema MT, Hassan A, Shaukat S, Sajid I. Endophytes and plant extracts of carica papaya linn. Exhibit promising antibacterial and in-vitro antitumor activity. J Anim Plant Sci. 2020; 30(4):1037–46.
13. Arif M, Yustisia I. The combination from ethanol extract of moringa leaves ( Moringa oleifera L .) and ethanol extract of papaya leaves ( Carica papaya L .) slows the tumor growth in sprague dawley rats induced. Med Clínica Práctica [Internet]. 2020 [cited 2020 May 11]; 3:100100. Available from:
14. Farida Y, Iswahyuni I. isolation , identification , and antioxidant activity of chemical compound in Ethanol Extract of Papaya Leaves (Carica Papaya). 2018; 11(1):4-7.
15. Rani N. Ecological Dyeing of Protein Fabrics with Carica papaya L . Leaf Natural Extract in the Presence of Bio-mordants as an Alternative Copartner to Metal Mordants. J Inst Eng Ser E [Internet]. 2020 [cited 2020 May 10]; Available from:
16. Kala CP. Medicinal & Aromatic Plants Leaf Juice of Carica papaya L.: A Remedy of Dengue Fever. 2012; 1(6):1–2.
17. Tahir N, Zaheer Z, Kausar S, Chiragh S. Prevention of fall in platelet count by carica papaya leaf juice in carboplatin induced thrombocytopaenia in Mice. 17(C):21-5.
18. Pandita A, Mishra N, Gupta G, Singh R. Use of papaya leaf extract in neonatal thrombocytopenia. Clin Case Reports. 2019; 7(3):497–9.
19. Owoyele B V., Adebukola OM, Funmilayo AA, Soladoye AO. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008; 16(4):168–73.
20. Imaga NO a, Gbenle GO, Okochi VI, Akanbi SO, Edeoghon SO, Oigbochie V, et al. Antisickling property of Carica papaya leaf extract. African J Biochem Res [Internet]. 2009 [cited 2020 May 16]; 3(4):102-6. Available from:
21. Chávez-Quintal P, González-Flores T, Rodríguez-Buenfil I, Gallegos-Tintoré S. Antifungal Activity in Ethanolic Extracts of Carica papaya L. cv. Maradol Leaves and Seeds. Indian J Microbiol. 2011; 51(1):54–60.
22. Julianti T, Oufir M, Hamburger M. Quantification of the antiplasmodial alkaloid carpaine in papaya (Carica Papaya) leaves. Planta Med. 2014; 80(13):1138-42.
23. Melariri P, Campbell W, Etusim P, Smith P. Antiplasmodial properties and bioassay-guided fractionation of ethyl acetate extracts from Carica papaya leaves. J Parasitol Res; 2011.
24. Gadge S, Game M, Salode V. Marvelous plant Carica papaya Linn : A herbal therapeutic option. 2020; 9(4):629-33.
25. Savla P, Das G, Mondal P, Gajbhiye RL, Jaisankar P, Ghosh S. Methanolic Extract of Papaya Leaves Shows Neuroprotective Effect. ChemistrySelect. 2017; 2(29):9454-7.
26. Bindhu KH, Vijayalakshmi A. Neuroprotective effect of Carica papaya leaf extract against aluminium toxicity: An experimental study on cognitive dysfunction and biochemical alterations in rats. Indian J Pharm Educ Res. 2019; 53(3):S392-s398.
27. Maniyar Y, Bhixavatimath P. Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn . leaves in alloxan-induced diabetic rats. 2012; 3(2):70–4.
28. Juárez-rojop IE, Díaz-zagoya JC, Ble-castillo JL, Miranda-osorio PH. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. 2012; (May 2014).
29. Mahmood AA, Sidik K, Salmah I. Wound Healing Activity of Carica papaya L. Aqueous Leaf Extract in Rats. Int J Mol Med Adv Sci. 2005; 1(4):398–401.
30. Abidah SN, Hadisaputro S, Hidayat ST. Effect of Carica Papaya l leaf on menstrual pain and prostaglandin level in adolescent with primary dysmenorrhea : a true experiment. 2017;3(3):198-204.
31. Imandiri A, Faizah R, Imandiri A. Acupuncture and Papaya Leaf Powder (Carica Papaya L) to Treat Dysmenorrhea. 2019; 15:37-8.
32. Sundaram SS, Suresh K. Prevention of hair fall and whitening of hair by valuable medicinal plants in selected areas of Madurai district, Tamil Nadu, India. J Med Plants Stud. 2019; 7(3):74-7.
33. Sari Y, Erwan E, Irawati E. Inclusion Different Level of Papaya Leaves Meal (Carica papaya L.) in Pellet Ration on Performance in Broiler Chickens. IOP Conf Ser Earth Environ Sci. 2020; 515(1).
34. Nwigwe US, Mbam SO, Umunakwe R. Evaluation of Carica papaya leaf extract as a bio-corrosion inhibitor for mild steel applications in a marine environment. Mater Res Express. 2019; 6(10).
60 Views | 72 Downloads
How to Cite
Sidat, P., A. I. Varachia, S. K. Vanshiya, A. H. Unagar, M. G. Akbari, and R. C. Dhamat. “Carica Papaya Leaves: One of Dynamic Plant Parts Having Multiple Therapeutic Activities”. Himalayan Journal of Health Sciences, Vol. 5, no. 3, Sept. 2020, pp. 37-48, doi:10.22270/hjhs.v5i3.67.
Review Article (s)