A Targeted Drug Delivery System for Cancer Treatment a Novel Approach: A Review
Abstract
In the recent scenario of the world there are millions of the people are suffering from the various types of cancer. To cure the cancer immunotherapy, radiation therapy, chemotherapy, surgery and hormonal therapy treatments are used. In treatment of cancer the convectional approaches are used which can adversely affect to normal cells on the body. Also, the side effects of this treatments are damage the immune system of the patient. To overcome such problems with the conventional treatment of the cancer the targeted drug delivery system is developed, in such oral delivery of drug at the particular location of tumor at perfect time with specific dosage. This review includes the development of the new targeted drug delivery system and its limitations.
Keywords:
Cancer pathophysiology, Drug Delivery, Targeted drug delivery, anti-cancer drugs
References
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31. Ezzati Nazhad Dolatabadi J, Valizadeh H, Hamishehkar H. Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs. Adv Pharm Bull. 2015;5(2):151-9.
32. Naik S, Patel D, Chuttani K, Mishra AK, Misra A. In vitro mechanistic study of cell death and in vivo performance evaluation of RGD grafted PEGylated docetaxel liposomes in breast cancer. Nanomedicine: nanotechnology, biology, and medicine. 2012; 8(6):951-62.
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34. Biswas S, Dodwadkar NS, Deshpande PP, Torchilin VP. Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Control Release. 2012;159(3):393-402.
35. Bhatt P, Lalani R, Vhora I, Patil S, Amrutiya J, Misra A, et al. Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation. International journal of pharmaceutics. 2018; 536(1):95-107.
36. Bhatt P, Lalani R, Mashru R, Misra A. Abstract 2065: Anti-FSHR antibody Fab’ fragment conjugated immunoliposomes loaded with cyclodextrin-paclitaxel complex for improved in vitro efficacy on ovarian cancer cells. Cancer research. 2016;76(14 Supplement):2065.
2. Jain RK. Barriers to drug delivery in solid tumors. Scientific American. 1994;271(1):58-65.
3. Bhatt P, Vhora I, Patil S, Amrutiya J, Bhattacharya C, Misra A, et al. Role of antibodies in diagnosis and treatment of ovarian cancer: Basic approach and clinical status. Journal of Controlled Release. 2016;226:148-67.
4. Lowenthal RM, Eaton K. TOXICITY OF CHEMOTHERAPY. Hematology /Oncology Clinics. 1996; 10(4):967-90.
5. Ruggeri B, Zhang SY, Caamano J, DiRado M, Flynn SD, Klein-Szanto AJ. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene. 1992;7(8):1503-11.
6. Yewale C, Baradia D, Patil S, Bhatt P, Amrutiya J, Gandhi R, et al. Docetaxel loaded immunonanoparticles delivery in EGFR overexpressed breast carcinoma cells. Journal of Drug Delivery Science and Technology. 2018;45:334-45.
7. Esposito M, Kang Y. Targeting tumor-stromal interactions in bone metastasis. Pharmacol Ther. 2014;141(2):222-33.
8. Feng Y, Sun B, Li X, Zhang L, Niu Y, Xiao C, et al. Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients. Breast cancer research and treatment. 2007;103(3):319-29.
9. Dreis S, Rothweiler F, Michaelis M, Cinatl J, Jr., Kreuter J, Langer K. Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles. International journal of pharmaceutics. 2007;341(1-2):207-14.
10. Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Molecular cancer research : MCR. 2006;4(4):221-33.
11. Yanasarn N, Sloat B, Cui Z. Nanoparticles Engineered from Lecithin-in-Water Emulsions As A Potential Delivery System for Docetaxel. International journal of pharmaceutics. 2009; 379: 174-80.
12. Park C, Youn H, Kim H, Noh T, Kook YH, Oh ET, et al. Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug. Journal of Materials Chemistry. 2009;19(16):2310-5.
13. Cosco D, Paolino D, Muzzalupo R, Celia C, Citraro R, Caponio D, et al. Novel PEG-coated niosomes based on bola-surfactant as drug carriers for 5-fluorouracil. Biomedical microdevices. 2009; 11(5):1115-25.
14. Chakravarthi S, Robinson D, De S. Nanoparticles Prepared Using Natural and Synthetic Polymers. 2007. p. 51-60.
15. P. Patel et al. Surface Modification of Nanoparticles for Targeted Drug Delivery. In Surface Modification of Nanoparticles for Targeted Drug Delivery ,Cham: Springer International Publishing. 2019:19-31.
16. Grenha A. Chitosan nanoparticles: a survey of preparation methods. Journal of Drug Targeting. 2012; 20(4):291-300.
17. Kievit FM, Zhang M. Surface engineering of iron oxide nanoparticles for targeted cancer therapy. Accounts of chemical research. 2011; 44(10):853-62.
18. Kim SK, Foote MB, Huang L. The targeted intracellular delivery of cytochrome C protein to tumors using lipid-apolipoprotein nanoparticles. Biomaterials. 2012; 33(15):3959-66.
19. Kılıçay E, Demirbilek M, Türk M, Güven E, Hazer B, Denkbas E. Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy. European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences. 2011; 44: 310-20.
20. Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J Control Release. 2016;240:77-92.
21. He L, Wang GL, Zhang Q. An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile. International journal of pharmaceutics. 2003; 250(1):45-50.
22. Luo X, Xie C, Wang H, Liu C, Yan S, Li X. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation. International journal of pharmaceutics. 2012;425(1):19-28.
23. Nagaich DU, Deepak P, Sharma A, Gulati N, Chaudhary A. POLYMERIC MICELLES: POTENTIAL DRUG DELIVERY DEVICES. Indonesian Journal of Pharmacy. 2013;24:223-38.
24. Aliabadi HM, Lavasanifar A. Polymeric micelles for drug delivery. Expert opinion on drug delivery. 2006;3(1):139-62.
25. Nishiyama N, Okazaki S, Cabral H, Miyamoto M, Kato Y, Sugiyama Y, et al. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer research. 2003;63(24):8977-83.
26. Bae Y, Jang WD, Nishiyama N, Fukushima S, Kataoka K. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Molecular bioSystems. 2005;1(3):242-50.
27. Kulthe S, Choudhari Y, Inamdar N, Mourya VK. Polymeric Micelles: Authoritative Aspects for Drug Delivery. Designed Monomers and Polymers. 2012;15.
28. Jain A, Agarwal A, Majumder S, Lariya N, Khaya A, Agrawal H, et al. Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug. J Control Release. 2010;148(3):359-67.
29. Teskac K, Kristl J. The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. International journal of pharmaceutics. 2010;390(1):61-9.
30. Raouane M, Desmaële D, Urbinati G, Massaad-Massade L, Couvreur P. Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery. Bioconjugate Chemistry. 2012;23(6):1091-104.
31. Ezzati Nazhad Dolatabadi J, Valizadeh H, Hamishehkar H. Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs. Adv Pharm Bull. 2015;5(2):151-9.
32. Naik S, Patel D, Chuttani K, Mishra AK, Misra A. In vitro mechanistic study of cell death and in vivo performance evaluation of RGD grafted PEGylated docetaxel liposomes in breast cancer. Nanomedicine: nanotechnology, biology, and medicine. 2012; 8(6):951-62.
33. Lalani RA, Bhatt P, Rathi M, Misra A. Abstract 2063: Improved sensitivity and in vitro efficacy of RGD grafted PEGylated gemcitabine liposomes in RRM1 siRNA pretreated cancer cells. Cancer research. 2016;76(14 Supplement):2063.
34. Biswas S, Dodwadkar NS, Deshpande PP, Torchilin VP. Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Control Release. 2012;159(3):393-402.
35. Bhatt P, Lalani R, Vhora I, Patil S, Amrutiya J, Misra A, et al. Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation. International journal of pharmaceutics. 2018; 536(1):95-107.
36. Bhatt P, Lalani R, Mashru R, Misra A. Abstract 2065: Anti-FSHR antibody Fab’ fragment conjugated immunoliposomes loaded with cyclodextrin-paclitaxel complex for improved in vitro efficacy on ovarian cancer cells. Cancer research. 2016;76(14 Supplement):2065.
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How to Cite
Champanery, R., and K. Patel. “A Targeted Drug Delivery System for Cancer Treatment a Novel Approach: A Review”. Himalayan Journal of Health Sciences, Vol. 5, no. 2, June 2020, pp. 19-27, doi:10.22270/hjhs.v5i2.58.
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