Cucurbitacins and its Anticancer property: A Review

  • Ashmi Samuel
DOI https://doi.org/10.22270/hjhs.v4i4.46

Abstract

Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

Keywords: Cucurbitacin, STAT, Janus kinase (JAK), anti-tumor, anti-inflammation, apoptosis

References

1. Gry J, Søborg I, Andersson HC. Cucurbitacins in plant food. Vol. 556. Tema Nord Nordic Council of Ministers; Ekspressen Tryk & Kopicenter; Copenhagen: Identity physical and chemical properties and analytical methods; 2006.p. 17-22.
2. Aliabadi HM, Lavasanifar A. Polymeric micelles for drug delivery. Expert Opin Drug Deliv. 2006; 3:139-62.
3. Kwon GK, Forrest ML. Amphiphilic block copolymer micelles for nanoscale drug delivery. Drug Dev Res. 2006; 67:15-22.
4. Molavi O, Ma Z, Mahmud A, Alshamsan A, Samuel J, Lai R, Kwon GS, Lavasanifar A. Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. Int J Pharmaceutics. 2008; 347:118-27.
5. Clericuzio M, Mella M, Vita-Finzi P, Zema M, Vidari G. Cucurbitane triterpenoids from Leucopaxillus gentianeus. J Nat Prod. 2004; 67:1823-8.
6. Recio MC, Prieto M, Bonucelli, Orsi C, Manez S, Giner RM, Cerda-Nicolas M, Rios JL. Anti-inflammation activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med. 2004; 70:414-20.
7. Leaman DW, Pisharody S, Flickinger TW, Commane MA, Schlessinger J, Kerr IM. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell Biol. 1996; 16:369-75.
8. Hirano T, Nakajima K, Hibi M. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 1997; 8:241-52.
9. Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell JE, Jr, Yancopoulos GD. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 1995; 267:1349-53.
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How to Cite
Samuel, A. “Cucurbitacins and Its Anticancer Property: A Review”. Himalayan Journal of Health Sciences, Vol. 4, no. 4, Dec. 2019, pp. 17-23, doi:10.22270/hjhs.v4i4.46.
Issue
Volume 4, Issue 4 Oct – Dec, 2019
Section
Review Article (s)
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