EFFECT OF ETHANOLIC FRUITS EXTRACT OF EMBELIA RIBES BURM ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN MICE

  • Naveen Garg
  • Prashant Mathur
  • Rohit Saraswat
  • Chandrachud Sharma

Abstract

This study was designed to examine the effect of ethanolic fruits extract of Embelia ribes Burm on dexamethasone-(1mg/kg, intramuscular, 22 days) induced Insulin resistance in Mice. Twenty two  days of oral feeding the extract (100 mg/kg and 200 mg/kg) to induced mice resulted in significant (P < .01) decrease in blood glucose, triglyeride, Insulin, HOMA-IR index and  increase in body weight  levels as compared to dexa control mice. Further, the extract also significantly (P < .01) decreased the MDA levels and significantly (P < .01) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in Hepatic tissue of dexa control  mice and also increased glucose uptake by skeletal muscle. The results of test drug were comparable to pioglitazone (2 mg/kg, i.m , 22 days), a standard antihyperglycemic agent.


The study concludes that Embelia ribes enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and Embelia ribes may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.

Keywords: Diabetes, Hyperinsulinemia, NIDDM, insulin resistance

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How to Cite
Garg, N., P. Mathur, R. Saraswat, and C. Sharma. “EFFECT OF ETHANOLIC FRUITS EXTRACT OF EMBELIA RIBES BURM ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN MICE”. Himalayan Journal of Health Sciences, Vol. 1, no. 2, Dec. 2018, pp. 4-9, doi:10.22270/ijist.v1i2.31.
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