Implantable Drug Delivery Systems
Traditional drug delivery methods provide very little, if any, control over the timing and pattern of drug release Medication concentration absorption at the point of action. Undefined medication concentration in plasma is a typical and obvious issue with the traditional dose method. Thus to overcome such problems efforts have been made by researchers and pharmaceutical scientists to the betterment of the drug delivery system and that lead to the development of the Novel Drug Delivery System (NDDS). NDDS is the approach and technology to deliver the drug in low concentration and follow the zero-order release of the drug in a controlled manner. Additionally, the NDDS's development results in the creation of an implantable drug delivery system (IDDS). a system for implantable medication delivery is a new approach of medicine delivery In this technique, the medicine is delivered under controlled conditions to the precise location where the implant is placed. The formulation, preparation, evaluation criteria, and future aspects of the implantable drug delivery system are the subjects of this study.
2. Pintoo Sharma, Mayank Phagna, & Reena Badhwar. Original Aspect and Future Administration in the Treatment of Heart Failure. Future Journal of Pharmaceuticals and Health Sciences. 2022;2(4):311-320.
3. Danckwerts M, Fassihi A. Implantable controlled release drug delivery systems: A Review. Drug Development and Industrial Pharmacy.1991;17(11):1465-502.
4. Gayathri DGNV, Kavya K, Dusanapudi Swathi, Aminabee SK, & Lakshmana Rao A. A Review on Brain Chip Technology. Future Journal of Pharmaceuticals and Health Sciences.2022;2(4):229-235.
5. Costantini LC, Kleppner SR, McDonough J, Azar MR, Patel R. Implantable technology for long-term delivery of nalmefene for treatment of alcoholism. International Journal of Pharmaceutics.2004;283:35-44.
6. Dinesh Kumar Kukunuri, Richard Noah, Sugreev Dwivedi Anuj, & SasiKarnati. Prescribing Patterns of Anticonvulsant Drugs in Epilepsy in a Tertiary care Hospital: An Observational Prospective Study. International Journal of Clinical Pharmacokinetics and Medical Sciences.2021;1(2): 54-69.
7. Zur G, Linder-Ganz E, Elsner J.J, Shani J, Brenner O, Agar G, Hershman E.B, Arnoczky S.P, Guilak F, Shterling A. Chondroprotective effects of a polycarbonate-urethane meniscal implant: Histopathological results in a sheep model. The Knee Surgery, Sports Traumatology, Arthroscopy. 2011; 19(2):255-263.
8. Soeb Hussain, Dharmendra Solanki, Rajat Yadav, Yusuf Khan. Implantable drug delivery systems: An Overview.International Journal of Pharmacy and Pharmaceutical Research. 2021;20(4):473–511
9. Ramesh, Y., Kothapalli, C., & Reddigari, J. R. A novel approaches on ocular drug delivery system. Journal of Drug Delivery and Therapeutics. 2017;7(6):117-124.
10. laes L, Ignatius A. Development of new, biodegradable implants. Chirurg. 2002;73(10):990-996.
11. Tian W, Mahmoudi M, Lhermusier T, Kiramijyan S, Chen F, Torguson R, Suddath W.O, Satler L.F, Pichard A.D, Waksman R. The influence of advancing age on implantation of drug-eluting stents. Catheterization Cardiovascular Interventions. 2016;88(4):516–521.
12. Bourges J. L, Bloquel C, Thomas A, Froussart F, Bochot A, Azan F, Gurny R, BenEzra D, Behar-Cohen F. IntraocularImplants for Extended Drug Delivery: Therapeutic Applications. Advanced Drug Delivery Reviews. 2006;58(11):1182-1202.
13. Sarah A. Stewart, Juan Domínguez-Robles, Ryan F. Donnelly, and EnekoLarrañeta; Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications; Polymers (Basel). 2018 Dec;10(12):1379.
14. Rajgor N., Bhaskar V., Patel M. Implantable drug delivery systems: An overview. Syst. Rev. Pharm. 2011;2:91–95.
15. Dash A., Cudworth G. Therapeutic applications of implantable drug delivery systems. J. Pharmacol. Toxicol. Methods.1998;40:1-12.
16. Fialho S.L., da Silva Cunha A. Manufacturing Techniques of Biodegradable Implants Intended for Intraocular Application. Drug Deliv. 2005;12:109-116.
17. Islam S, Islam S, Urmi AB. Observation of the release of aspirin from gelatin-sodium alginate polymeric implant. Journal of Chemistry and Pharmaceutical Research. 2012;4(12):5149-5156.
18. Rabin C., Liang Y., Ehrlichman R.S., Budhian A., Metzger K.L., Majewski-Tiedeken C., Winey K.I., Siegel S.J. In vitro and in vivo demonstration of risperidone implants in mice. Schizophr. Res. 2008;98:66-78.
19. Karina CR, Riesta P, Esti H. Preparation and evaluation of ciprofloxacin implants using bovine hydroxyapatite-chitosan composite and glutaraldehyde for osteomyelitis. International Journal of Pharmacy and Pharmaceutical Sciences. 2016;8(1):45- 51.
20. Schlesinger E., Johengen D., Luecke E., Rothrock G., McGowan I., van der Straten A., Desai T. A Tunable, Biodegradable, Thin-Film Polymer Device as a Long-Acting Implant Delivering Tenofovir Alafenamide Fumarate for HIV Pre-exposure Prophylaxis. Pharm. Res. 2016;33:1649–1656.
21. Purushotham RK, Jaybhaye SI, Ravindra K, Bhandari A, Pratima S. Designing of Diclofenac Sodium Biodegradable Drug Implant for Speedy Fracture Healing. Journal of Chemistry and Pharmaceutical Research. 2010; 3(1):330-337.
22. Sarah A Stewart, Juan Dominguez-Robles, Ryan F Donnelly, EnekoLarraneta. Implantable polymeric drug delivery devices: classification, manufacture, materials, and clinical applications. Polymers. 2018;10(12):1379.
23. VasirJ.K, Tambwekar K. and Garg, S. Bioadhesive microspheres implants as a controlled drug delivery system. International journal of pharmaceutics. 2003:255(1-2):13
24. Colaris M.J.L., de Boer M., van der Hulst R.R., Cohen Tervaert J.W. Two hundreds cases of ASIA syndrome following silicone implants: A comparative study of 30 years and a review of current literature. Immunol. Res.2017;65:120-128.
25. Claes L., Ignatius A. Development of new, biodegradable implants. Chirurg. 2002;73:990-996.
26. Rahman S, Gulati K, Kogawa M, Atkins GJ, Pivonka P, Findlay DM, Losic D. Drug diffusion, integration, and stability of nanoengineered drug-releasing implants in bone ex-vivo. Journal of Biomedical Materials Research. Part A. 2016;104(3):714-725.
27. Kaurav H, Kapoor DN. Implantable systems for drug delivery to the brain. Therapeutic Delivery.2017; 8(12):1097-1107.
28. Ahmed KK, Tamer MA, Ghareeb MM, Salem AK. Recent Advances in Polymeric Implants.AAPS PharmSciTech. 2019;20(7):300.
29. Pothupitiya JU, Zheng C, Saltzman WM. Synthetic biodegradable polyesters for implantable controlled-release devices.Expert Opinion on Drug Delivery. 2022;19(10):1351-1364.
30. Fayzullin, A.; Bakulina, A.; Mikaelyan, K.; Shekhter, A.; Guller, A. Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape. Bioengineering. 2021;8:205.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The International Journal of Innovative Science & Technology affairs require a formal written transfer of copyright from the author(s) for each article published. We therefore ask you to complete and return this form, retaining a copy for your records. Your cooperation is essential and appreciated. Any delay will result in a delay in publication.
I/we have read and agree with the terms and conditions stated Page 2 of this agreement and I/we hereby confirm the transfer of all copyrights in and relating to the above-named manuscript, in all forms and media, now or hereafter known, to the International Journal of Drug Regulatory affairs, effective from the date stated below. I/we acknowledge that the IJDRA is relying on this agreement in publishing the above-named manuscript. However, this agreement will be null and void if the manuscript is not published in the IJIST.
Download link for COPYRIGHT FORM