Anti-inflammatory drugs with therapeutic effects and drug regulators

  • Prateek Paul Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj
  • Manvi . Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj

Abstract

For prostaglandin production, the enzyme cyclooxygenase (COX) is required. The two COX isoforms are constitutive COX-1 (which is responsible for physiological functions) and inducible COX-2 (involved in inflammation). COX inhibition explains both the medicinal (inhibition of COX-2) and negative effects (inhibition of COX-1) effects of non-steroidal anti-inflammatory medicines (NSAIDs). Nonsteroidal anti-inflammatory medicines (NSAIDs) act by blocking the enzyme cyclooxygenase (COX), which produces prostaglandins (PGs). To a greater or lesser extent, they share similar side effects, such as stomach and renal toxicity. According to a recent study, there are at least two COX isoenzymes. COX-1 is a naturally occurring enzyme that creates prostaglandins (PGs), which protect the stomach and kidneys. Aspirin's well-known anti-cancer impact could also be related to its influence on COX-2, which is expressed in this condition. As a result, selective COX-2 inhibitors may have new therapeutic potential as anticancer drugs, as well as in preventing premature labor and maybe reducing the progression of Alzheimer's disease.

Keywords: cyclooxygenase, NASIDs, inflammation, colon cancer, anticancer agent

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How to Cite
Paul, P., and M. . “Anti-Inflammatory Drugs With Therapeutic Effects and Drug Regulators”. Himalayan Journal of Health Sciences, Vol. 6, no. 3, Sept. 2021, pp. 30-39, doi:10.22270/hjhs.v6i3.106.
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